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Best Longevity Supplements: The Cellular-Aging Stack
Longevity science has moved from theory to actionable protocols. The compounds with the strongest human and animal evidence target the hallmarks of aging: mitochondrial decline, senescent cell burden, epigenetic drift, and impaired autophagy.
The four evidence-based longevity pillars
NAD+ precursors (NMN / NR) restore cellular energy. Resveratrol activates sirtuins. Spermidine induces autophagy. Quercetin acts as a mild senolytic clearing damaged cells. Together they address multiple hallmarks simultaneously.
The Nūjeva longevity protocol
Daily: NMN 500 mg + resveratrol 500 mg (with fat) + spermidine 1 mg. Weekly pulse: quercetin + fisetin for senolytic clearance. Layered on top of exercise, sleep, and caloric moderation — the non-negotiables.
Frequently asked questions
What is the best longevity supplement?
The strongest evidence supports NAD+ precursors (NMN or NR). Layer resveratrol, spermidine, and quercetin for a broader-spectrum protocol.
Do longevity supplements actually extend lifespan?
Human lifespan trials take decades, but multiple biomarkers of aging (methylation age, insulin sensitivity, muscle NAD+) improve measurably with these interventions.